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piggyBac Insertional Mutagenesis Screen Identifies a Role for Nuclear RHOA in Human ES Cell Differentiation

The mechanisms regulating human embryonic stem (ES) cell self-renewal and differentiation are not well defined in part due to the lack of tools for forward genetic analysis. We present a piggyBac transposon gain of function screen in human ES cells that identifies DENND2C, which genetically cooperat...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Gayle, Sophia, Pan, Yukun, Landrette, Sean, Xu, Tian
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437468/
https://ncbi.nlm.nih.gov/pubmed/25866159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.03.001
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