Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis

Tumor cells must overcome apoptosis to survive throughout metastatic dissemination and distal organ colonization. Here we show in the Polyoma Middle T mammary tumor model that N-cadherin expression causes Slug upregulation, which in turn promotes carcinoma cell survival. Slug was dramatically upregu...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Kim, Seaho, Yao, Jiahong, Suyama, Kimita, Qian, Xia, Qian, Bin-Zhi, Bandyopadhyay, Sanmay, Loudig, Olivier, De Leon-Rodriguez, Carlos, Zhou, Zhen Ni, Segall, Jeffrey, Macian, Fernando, Norton, Larry, Hazan, Rachel. B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437462/
https://ncbi.nlm.nih.gov/pubmed/24830722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2591
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