Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids

l-Glutamine (Gln) is a key metabolic fuel for intestinal epithelial cell proliferation and survival and may be conditionally essential for gut homeostasis during catabolic states. We show that l-alanyl-l-glutamine (Ala-Gln), a stable Gln dipeptide, protects mice against jejunal crypt depletion in th...

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Bibliografiset tiedot
Julkaisussa:Am J Physiol Gastrointest Liver Physiol
Päätekijät: Moore, Sean R., Guedes, Marjorie M., Costa, Tie B., Vallance, Jefferson, Maier, Elizabeth A., Betz, Kristina J., Aihara, Eitaro, Mahe, Maxime M., Lima, Aldo A. M., Oriá, Reinaldo B., Shroyer, Noah F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2015
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Call for Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437023/
https://ncbi.nlm.nih.gov/pubmed/25792564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00422.2014
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