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Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids
l-Glutamine (Gln) is a key metabolic fuel for intestinal epithelial cell proliferation and survival and may be conditionally essential for gut homeostasis during catabolic states. We show that l-alanyl-l-glutamine (Ala-Gln), a stable Gln dipeptide, protects mice against jejunal crypt depletion in th...
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Publicado no: | Am J Physiol Gastrointest Liver Physiol |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4437023/ https://ncbi.nlm.nih.gov/pubmed/25792564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00422.2014 |
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