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Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing

The OLR1 gene encodes the oxidized low-density lipoprotein receptor (LOX-1), which is responsible for the cellular uptake of oxidized LDL (Ox-LDL), foam cell formation in atheroma plaques and atherosclerotic plaque rupture. Alternative splicing (AS) of OLR1 exon 5 generates two protein isoforms with...

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Bibliografski detalji
Izdano u:RNA
Glavni autori: Tejedor, J. Ramón, Tilgner, Hagen, Iannone, Camilla, Guigó, Roderic, Valcárcel, Juan
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436670/
https://ncbi.nlm.nih.gov/pubmed/25904137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.049890.115
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