Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype for caseinolytic protease (ClpP1P2) activity...

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Publicado en:mBio
Main Authors: Moreira, Wilfried, Ngan, Grace J. Y., Low, Jian Liang, Poulsen, Anders, Chia, Brian C. S., Ang, Melgious J. Y., Yap, Amelia, Fulwood, Justina, Lakshmanan, Umayal, Lim, Jolander, Khoo, Audrey Y. T., Flotow, Horst, Hill, Jeffrey, Raju, Ravikiran M., Rubin, Eric J., Dick, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Microbiology 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436076/
https://ncbi.nlm.nih.gov/pubmed/25944857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00253-15
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