Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype for caseinolytic protease (ClpP1P2) activity...

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Udgivet i:mBio
Main Authors: Moreira, Wilfried, Ngan, Grace J. Y., Low, Jian Liang, Poulsen, Anders, Chia, Brian C. S., Ang, Melgious J. Y., Yap, Amelia, Fulwood, Justina, Lakshmanan, Umayal, Lim, Jolander, Khoo, Audrey Y. T., Flotow, Horst, Hill, Jeffrey, Raju, Ravikiran M., Rubin, Eric J., Dick, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436076/
https://ncbi.nlm.nih.gov/pubmed/25944857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00253-15
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