Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype for caseinolytic protease (ClpP1P2) activity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:mBio
Prif Awduron: Moreira, Wilfried, Ngan, Grace J. Y., Low, Jian Liang, Poulsen, Anders, Chia, Brian C. S., Ang, Melgious J. Y., Yap, Amelia, Fulwood, Justina, Lakshmanan, Umayal, Lim, Jolander, Khoo, Audrey Y. T., Flotow, Horst, Hill, Jeffrey, Raju, Ravikiran M., Rubin, Eric J., Dick, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Microbiology 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436076/
https://ncbi.nlm.nih.gov/pubmed/25944857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00253-15
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg