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Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype for caseinolytic protease (ClpP1P2) activity...

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מידע ביבליוגרפי
הוצא לאור ב:	mBio
Main Authors:	Moreira, Wilfried, Ngan, Grace J. Y., Low, Jian Liang, Poulsen, Anders, Chia, Brian C. S., Ang, Melgious J. Y., Yap, Amelia, Fulwood, Justina, Lakshmanan, Umayal, Lim, Jolander, Khoo, Audrey Y. T., Flotow, Horst, Hill, Jeffrey, Raju, Ravikiran M., Rubin, Eric J., Dick, Thomas
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society of Microbiology 2015
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4436076/ https://ncbi.nlm.nih.gov/pubmed/25944857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00253-15
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Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

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