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Complete release of (5′S)-8,5′-cyclo-2′-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions

8,5′-Cyclopurine-2′-deoxynucleosides in DNA are repaired by nucleotide-excision repair, and act as strong blocks to DNA polymerases, RNA polymerase II and transcription factor binding. Thus, it is important to accurately determine the level of these lesions in DNA. There is controversy in the litera...

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Detalles Bibliográficos
Autores principales: Jaruga, Pawel, Theruvathu, Jacob, Dizdaroglu, Miral, Brooks, Philip J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC443555/
https://ncbi.nlm.nih.gov/pubmed/15215337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh087
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