A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

Immunization with live-attenuated Plasmodium sporozoites completely protects against malaria infection. Genetic engineering offers a versatile platform to create live-attenuated sporozoite vaccine candidates. We previously generated a genetically attenuated parasite (GAP) by deleting the P52 and P36...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Mikolajczak, Sebastian A, Lakshmanan, Viswanathan, Fishbaugher, Matthew, Camargo, Nelly, Harupa, Anke, Kaushansky, Alexis, Douglass, Alyse N, Baldwin, Michael, Healer, Julie, O'Neill, Matthew, Phuong, Thuan, Cowman, Alan, Kappe, Stefan H I
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435496/
https://ncbi.nlm.nih.gov/pubmed/24827907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.85
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