Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model

We investigated the biological activity of W9, a bone resorption inhibitor peptide, using NanoClik nanoparticles as an injectable carrier, where acryloyl group-modified cholesterol-bearing pullulan (CHPOA) nanogels were crosslinked by pentaerythritol tetra (mercaptoethyl) polyoxyethylene. Thirty 5-w...

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Detalles Bibliográficos
Publicado en:Int J Nanomedicine
Autores principales: Sato, Toshimi, Alles, Neil, Khan, Masud, Nagano, Kenichi, Takahashi, Mariko, Tamura, Yukihiko, Shimoda, Asako, Ohya, Keiichi, Akiyoshi, Kazunari, Aoki, Kazuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435441/
https://ncbi.nlm.nih.gov/pubmed/25999711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S61566
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