The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study

INTRODUCTION: We designed OP3-4 (YCEIEFCYLIR), a cyclic peptide, to mimic the soluble osteoprotegerin (OPG), and was proven to bind to RANKL (receptor activator of NF-κB ligand), thereby inhibiting osteoclastogenesis. We recently found that another RANKL binding peptide, W9, could accelerate bone fo...

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Pubblicato in:Arthritis Res Ther
Autori principali: Kato, Genki, Shimizu, Yasuhiro, Arai, Yuki, Suzuki, Natsuki, Sugamori, Yasutaka, Maeda, Miki, Takahashi, Mariko, Tamura, Yukihiko, Wakabayashi, Noriyuki, Murali, Ramachandran, Ono, Takashi, Ohya, Keiichi, Mise-Omata, Setsuko, Aoki, Kazuhiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570694/
https://ncbi.nlm.nih.gov/pubmed/26373710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0753-8
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