Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

Tuberous sclerosis complex (TSC) and Peutz-Jeghers syndrome (PJS) are dominantly inherited benign tumor syndromes that share striking histopathological similarities. Here we show that LKB1, the gene mutated in PJS, acts as a tumor suppressor by activating TSC2, the gene mutated in TSC. Like TSC2, LK...

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Hlavní autoři: Corradetti, Michael N., Inoki, Ken, Bardeesy, Nabeel, DePinho, Ronald A., Guan, Kun-Liang
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC443516/
https://ncbi.nlm.nih.gov/pubmed/15231735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1199104
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