Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

Most peptides have not proved useful as neuroactive drugs because they are blocked by the blood-brain barrier and do not reach their receptors within the brain. Intraperitoneally administered L-serinyl beta-D-glucoside analogues of [Met5]enkephalin (glycopeptides) have been shown to be transported a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Polt, R, Porreca, F, Szabò, L Z, Bilsky, E J, Davis, P, Abbruscato, T J, Davis, T P, Harvath, R, Yamamura, H I, Hruby, V J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44349/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.7114
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