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Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

Most peptides have not proved useful as neuroactive drugs because they are blocked by the blood-brain barrier and do not reach their receptors within the brain. Intraperitoneally administered L-serinyl beta-D-glucoside analogues of [Met5]enkephalin (glycopeptides) have been shown to be transported a...

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Hlavní autoři: Polt, R, Porreca, F, Szabò, L Z, Bilsky, E J, Davis, P, Abbruscato, T J, Davis, T P, Harvath, R, Yamamura, H I, Hruby, V J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1994
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC44349/
https://ncbi.nlm.nih.gov/pubmed/8041755
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