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Anomalous rearrangements of the immunoglobulin heavy chain genes in human leukemias support the loop-out mechanism of class switch.

Discrete rearrangements of immunoglobulin genes are characteristic of lymphoproliferative diseases of B cells and provide direct evidence of their clonal nature. In addition, because leukemic transformation and growth may amplify B cell clones regardless of selection by antigen, analysis of rearrang...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Laffan, M, Luzzatto, L
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1992
Materias:
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443382/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1469088/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116117
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