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Hypercapnia Inhibits Autophagy and Bacterial Killing in Human Macrophages by Increasing Expression of Bcl-2 and Bcl-xL

Hypercapnia, the elevation of CO(2) in blood and tissue, commonly develops in patients with advanced lung disease and severe pulmonary infections, and is associated with high mortality. We previously reported that hypercapnia alters expression of host defense genes, inhibits phagocytosis, and increa...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Casalino-Matsuda, S. Marina, Nair, Aisha, Beitel, Greg J., Gates, Khalilah L., Sporn, Peter H. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433787/
https://ncbi.nlm.nih.gov/pubmed/25895534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500150
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