Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury.

Pyocyanin, a secretory product of Pseudomonas aeruginosa, has the capacity to undergo redox cycling under aerobic conditions with resulting generation of superoxide and hydrogen peroxide. By using spin trapping techniques in conjunction with electron paramagnetic resonance spectrometry (EPR), supero...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Britigan, B E, Roeder, T L, Rasmussen, G T, Shasby, D M, McCormick, M L, Cox, C D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443369/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1469082/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116104
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