Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury.

Pyocyanin, a secretory product of Pseudomonas aeruginosa, has the capacity to undergo redox cycling under aerobic conditions with resulting generation of superoxide and hydrogen peroxide. By using spin trapping techniques in conjunction with electron paramagnetic resonance spectrometry (EPR), supero...

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Pubblicato in:	J Clin Invest
Autori principali:	Britigan, B E, Roeder, T L, Rasmussen, G T, Shasby, D M, McCormick, M L, Cox, C D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1469082/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116104
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