Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro.

Pseudomonas aeruginosa culture filtrates varied in their ability to slow human ciliary beat frequency (7-71%). This activity did not correlate with known virulence factors. However, a close correlation (r = 0.97) existed between ciliary slowing and pigment content. In a prolonged culture, the increa...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Wilson, R, Pitt, T, Taylor, G, Watson, D, MacDermot, J, Sykes, D, Roberts, D, Cole, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424027/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3098783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112787
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