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Measuring the Activity of Leucine-Rich Repeat Kinase 2: A Kinase Involved in Parkinson's Disease

Mutations in the LRRK2 (Leucine-Rich Repeat Kinase 2) gene are the most common cause of autosomal dominant Parkinson's disease. LRRK2 has multiple functional domains including a kinase domain. The kinase activity of LRRK2 is implicated in the pathogenesis of Parkinson's disease. Developing...

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Bibliographic Details
Published in:Methods Mol Biol
Main Authors: Lee, Byoung Dae, Li, Xiaojie, Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433534/
https://ncbi.nlm.nih.gov/pubmed/21960214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-337-0_3
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