PD-1 co-inhibitory and OX40 co-stimulatory crosstalk regulates helper T cell differentiation and anti-Plasmodium humoral immunity

The differentiation and protective capacity of Plasmodium-specific T cells are regulated by both positive and negative signals during malaria, but the molecular and cellular details remain poorly defined. Here we show that malaria patients and Plasmodium-infected rodents exhibit atypical expression...

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Veröffentlicht in:Cell Host Microbe
Hauptverfasser: Zander, Ryan A., Obeng-Adjei, Nyamekye, Guthmiller, Jenna J., Kulu, Divine I., Li, Jun, Ongoiba, Aissata, Traore, Boubacar, Crompton, Peter D., Butler, Noah S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433434/
https://ncbi.nlm.nih.gov/pubmed/25891357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.03.007
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