Small-molecule modulators of the OX40–OX40 ligand co-stimulatory protein–protein interaction

BACKGROUND AND PURPOSE: The OX40–OX40L protein–protein interaction (PPI) is an important cell-surface signalling co-stimulatory regulator within the TNFR superfamily (TNFRSF) and a promising therapeutic target for immunomodulation. PPIs are difficult to modulate using small-molecules. Here, we descr...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Song, Yun, Margolles-Clark, Emilio, Bayer, Allison, Buchwald, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294117/
https://ncbi.nlm.nih.gov/pubmed/24930776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12819
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