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Small-molecule modulators of the OX40–OX40 ligand co-stimulatory protein–protein interaction
BACKGROUND AND PURPOSE: The OX40–OX40L protein–protein interaction (PPI) is an important cell-surface signalling co-stimulatory regulator within the TNFR superfamily (TNFRSF) and a promising therapeutic target for immunomodulation. PPIs are difficult to modulate using small-molecules. Here, we descr...
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| Veröffentlicht in: | Br J Pharmacol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BlackWell Publishing Ltd
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294117/ https://ncbi.nlm.nih.gov/pubmed/24930776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12819 |
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