A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans.

To determine if insulin-like growth factor I (IGF-I) inhibits pulsatile growth hormone (GH) secretion in man, recombinant human IGF-I (rhIGF-I) was infused for 6 h at 10 micrograms.kg-1.h-1 during a euglycemic clamp in 10 normal men who were fasted for 32 h to enhance GH secretion. Saline alone was...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Hartman, M L, Clayton, P E, Johnson, M L, Celniker, A, Perlman, A J, Alberti, K G, Thorner, M O
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1993
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443305/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8514857/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116480
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