Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions

Engineering of the constant Fc part of monoclonal human IgG1 (hIgG1) Abs is an approach to improve effector functions and clinical efficacy of next-generation IgG1-based therapeutics. A main focus in such development is tailoring of in vivo half-life and transport properties by engineering the pH-de...

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Bibliografiset tiedot
Julkaisussa:J Immunol
Päätekijät: Grevys, Algirdas, Bern, Malin, Foss, Stian, Bratlie, Diane Bryant, Moen, Anders, Gunnarsen, Kristin Støen, Aase, Audun, Michaelsen, Terje Einar, Sandlie, Inger, Andersen, Jan Terje
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: AAI 2015
Aiheet:
Molecular and Structural Immunology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432726/
https://ncbi.nlm.nih.gov/pubmed/25904551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401218
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