Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions

Engineering of the constant Fc part of monoclonal human IgG1 (hIgG1) Abs is an approach to improve effector functions and clinical efficacy of next-generation IgG1-based therapeutics. A main focus in such development is tailoring of in vivo half-life and transport properties by engineering the pH-de...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Grevys, Algirdas, Bern, Malin, Foss, Stian, Bratlie, Diane Bryant, Moen, Anders, Gunnarsen, Kristin Støen, Aase, Audun, Michaelsen, Terje Einar, Sandlie, Inger, Andersen, Jan Terje
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2015
Fag:
Molecular and Structural Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432726/
https://ncbi.nlm.nih.gov/pubmed/25904551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401218
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