Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions

Engineering of the constant Fc part of monoclonal human IgG1 (hIgG1) Abs is an approach to improve effector functions and clinical efficacy of next-generation IgG1-based therapeutics. A main focus in such development is tailoring of in vivo half-life and transport properties by engineering the pH-de...

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Veröffentlicht in:J Immunol
Hauptverfasser: Grevys, Algirdas, Bern, Malin, Foss, Stian, Bratlie, Diane Bryant, Moen, Anders, Gunnarsen, Kristin Støen, Aase, Audun, Michaelsen, Terje Einar, Sandlie, Inger, Andersen, Jan Terje
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2015
Schlagworte:
Molecular and Structural Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432726/
https://ncbi.nlm.nih.gov/pubmed/25904551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401218
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