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The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation
Formins are actin polymerization factors that elongate unbranched actin filaments at the barbed end. Rho family GTPases activate Diaphanous-related formins through the relief of an autoregulatory interaction. The crystal structures of the N-terminal domains of human FMNL1 and FMNL2 in complex with a...
Enregistré dans:
| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Pub. Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432619/ https://ncbi.nlm.nih.gov/pubmed/25963737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8088 |
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