Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidney.
Renal reperfusion injury results from oxygen radical generation. During reoxygenation of hypoxic kidney cells, xanthine oxidase produces superoxide radical, which eventuates in hydroxyl radical formation by the Fenton reaction. This reaction, catalyzed by transition metals such as iron, is particula...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44326/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041736/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.7002 |
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