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2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.

MCF-7 breast tumor cells form multicellular foci in vitro when supplemented with 17 beta-estradiol (E2). In the presence of E2 and the aryl hydrocarbon-receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), MCF-7 cells grow to confluence but do not form foci. To investigate the role of E2 meta...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Spink, D C, Lincoln, D W, Dickerman, H W, Gierthy, J F
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1990
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54649/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2395886/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.17.6917
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