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Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy
Cyclic nucleotide-gated (CNG) channels are activated by binding of cyclic nucleotides. Although structural studies have identified the channel pore and selectivity filter, conformation changes associated with gating remain poorly understood. Here we combine single-molecule force spectroscopy (SMFS)...
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| 發表在: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432583/ https://ncbi.nlm.nih.gov/pubmed/25963832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8093 |
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