Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy

Cyclic nucleotide-gated (CNG) channels are activated by binding of cyclic nucleotides. Although structural studies have identified the channel pore and selectivity filter, conformation changes associated with gating remain poorly understood. Here we combine single-molecule force spectroscopy (SMFS)...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Maity, Sourav, Mazzolini, Monica, Arcangeletti, Manuel, Valbuena, Alejandro, Fabris, Paolo, Lazzarino, Marco, Torre, Vincent
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432583/
https://ncbi.nlm.nih.gov/pubmed/25963832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8093
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