Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

Hypertriglyceridemia is common in the general population, but its mechanism is largely unknown. In previous work human apo CIII transgenic (HuCIIITg) mice were found to have elevated triglyceride levels. In this report, the mechanism for the hypertriglyceridemia was studied. Two different HuCIIITg m...

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Pubblicato in:	J Clin Invest
Autori principali:	Aalto-Setälä, K, Fisher, E A, Chen, X, Chajek-Shaul, T, Hayek, T, Zechner, R, Walsh, A, Ramakrishnan, R, Ginsberg, H N, Breslow, J L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1430212/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116066
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