Mechanistic Insights into RNA Transphosphorylation from Kinetic Isotope Effects and Linear Free Energy Relationships of Model Reactions

Phosphoryl transfer reactions are ubiquitous in biology, and the understanding of the mechanisms whereby these reactions are catalyzed by protein and RNA enzymes is central to reveal design principles for new therapeutics. Two of the most powerful experimental probes of chemical mechanism involve th...

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Publicado en:Chemistry
Autores principales: Chen, Haoyuan, Giese, Timothy J., Huang, Ming, Wong, Kin-Yiu, Harris, Michael E., York, Darrin M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432475/
https://ncbi.nlm.nih.gov/pubmed/25223953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201403862
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