Open-Label, Single-Dose, Parallel-Group Study in Healthy Volunteers To Determine the Drug-Drug Interaction Potential between KAE609 (Cipargamin) and Piperaquine

KAE609 represents a new class of potent, fast-acting, schizonticidal antimalarials. This study investigated the safety and pharmacokinetics of KAE609 in combination with the long-acting antimalarial piperaquine (PPQ) in healthy volunteers. A two-way pharmacokinetic interaction was hypothesized for K...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Stein, Daniel S., Jain, Jay Prakash, Kangas, Michael, Lefèvre, Gilbert, Machineni, Surendra, Griffin, Paul, Lickliter, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432206/
https://ncbi.nlm.nih.gov/pubmed/25845867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00340-15
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