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Squalestatin Is an Inhibitor of Carotenoid Biosynthesis in Plasmodium falciparum

The increasing resistance of malaria parasites to almost all available drugs calls for the characterization of novel targets and the identification of new compounds. Carotenoids are polyisoprenoids from plants, algae, and some bacteria, and they are biosynthesized by Plasmodium falciparum but not by...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Gabriel, Heloisa B., Silva, Marcia F., Kimura, Emília A., Wunderlich, Gerhard, Katzin, Alejandro M., Azevedo, Mauro F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432196/
https://ncbi.nlm.nih.gov/pubmed/25779575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04500-14
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