Enantiomers of Nifurtimox Do Not Exhibit Stereoselective Anti-Trypanosoma cruzi Activity, Toxicity, or Pharmacokinetic Properties

With the aim of improving the available drugs for the treatment of Chagas disease, individual enantiomers of nifurtimox were characterized. The results indicate that the enantiomers are equivalent in their in vitro activity against a panel of Trypanosoma cruzi strains; in vivo efficacy in a murine m...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Moraes, Carolina B., White, Karen L., Braillard, Stéphanie, Perez, Catherine, Goo, Junghyun, Gaspar, Luis, Shackleford, David M., Cordeiro-da-Silva, Anabela, Thompson, R. C. Andrew, Freitas-Junior, Lucio, Charman, Susan A., Chatelain, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432195/
https://ncbi.nlm.nih.gov/pubmed/25845874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05139-14
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