Enantiomers of Nifurtimox Do Not Exhibit Stereoselective Anti-Trypanosoma cruzi Activity, Toxicity, or Pharmacokinetic Properties

With the aim of improving the available drugs for the treatment of Chagas disease, individual enantiomers of nifurtimox were characterized. The results indicate that the enantiomers are equivalent in their in vitro activity against a panel of Trypanosoma cruzi strains; in vivo efficacy in a murine m...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Moraes, Carolina B., White, Karen L., Braillard, Stéphanie, Perez, Catherine, Goo, Junghyun, Gaspar, Luis, Shackleford, David M., Cordeiro-da-Silva, Anabela, Thompson, R. C. Andrew, Freitas-Junior, Lucio, Charman, Susan A., Chatelain, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432195/
https://ncbi.nlm.nih.gov/pubmed/25845874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05139-14
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