Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo

Hematopoietic stem cells (HSCs) are localized within specialized microenvironments throughout the BM. Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are important in the perivascular space. Rac is critical for MSC cell shape in vitro, whereas its function in MSCs in vivo remains poor...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ciuculescu, Marioara F., Park, Shin-Young, Canty, Kimberly, Mathieu, Ronald, Silberstein, Leslie E., Williams, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432004/
https://ncbi.nlm.nih.gov/pubmed/25824687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604892
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