Parvalbumin/Somatostatin Ratio Is Increased in Pten mutant Mice and by Human PTEN ASD alleles

Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here we investigate the function of Pten in cortical GABAergic neurons using conditional mutagenesis in mice. Loss of Pten results in a preferential loss of SST(+) interneurons, that increases the ratio of P...

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Publié dans:Cell Rep
Auteurs principaux: Vogt, Daniel, Cho, Kathleen K. A., Lee, Anthony T., Sohal, Vikaas S., Rubenstein, John L. R.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431948/
https://ncbi.nlm.nih.gov/pubmed/25937288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.019
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