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Parvalbumin/Somatostatin Ratio Is Increased in Pten mutant Mice and by Human PTEN ASD alleles
Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here we investigate the function of Pten in cortical GABAergic neurons using conditional mutagenesis in mice. Loss of Pten results in a preferential loss of SST(+) interneurons, that increases the ratio of P...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4431948/ https://ncbi.nlm.nih.gov/pubmed/25937288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.019 |
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