ATM couples replication stress and metabolic reprogramming during cellular senescence

Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized by metabolic...

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Udgivet i:Cell Rep
Main Authors: Aird, Katherine M., Worth, Andrew J., Snyder, Nathaniel W., Lee, Joyce V., Sivanand, Sharanya, Liu, Qin, Blair, Ian A., Wellen, Kathryn E., Zhang, Rugang
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431925/
https://ncbi.nlm.nih.gov/pubmed/25937285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.014
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