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ATM couples replication stress and metabolic reprogramming during cellular senescence

Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized by metabolic...

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Podrobná bibliografie
Vydáno v:Cell Rep
Hlavní autoři: Aird, Katherine M., Worth, Andrew J., Snyder, Nathaniel W., Lee, Joyce V., Sivanand, Sharanya, Liu, Qin, Blair, Ian A., Wellen, Kathryn E., Zhang, Rugang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431925/
https://ncbi.nlm.nih.gov/pubmed/25937285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.014
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