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ATM couples replication stress and metabolic reprogramming during cellular senescence
Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized by metabolic...
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| Vydáno v: | Cell Rep |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4431925/ https://ncbi.nlm.nih.gov/pubmed/25937285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.014 |
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