Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

Glucose and glutamine are the two principal nutrients that cancer cells use to proliferate and survive. Many cancers show altered glucose metabolism, which constitutes the basis for in vivo positron emission tomography (PET) imaging with (18)F-fluorodeoxyglucose ((18)F-FDG). However, (18)F-FDG is in...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Venneti, Sriram, Dunphy, Mark P., Zhang, Hanwen, Pitter, Kenneth L., Zanzonico, Patrick, Campos, Carl, Carlin, Sean D., La Rocca, Gaspare, Lyashchenko, Serge, Ploessl, Karl, Rohle, Daniel, Omuro, Antonio M., Cross, Justin R., Brennan, Cameron W., Weber, Wolfgang A., Holland, Eric C., Mellinghoff, Ingo K., Kung, Hank F., Lewis, Jason S., Thompson, Craig B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431550/
https://ncbi.nlm.nih.gov/pubmed/25673762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa1009
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