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A mRNA-Responsive G-Quadruplex-Based Drug Release System

G-quadruplex-based drug delivery carriers (GDDCs) were designed to capture and release a telomerase inhibitor in response to a target mRNA. Hybridization between a loop on the GDDC structure and the mRNA should cause the G-quadruplex structure of the GDDC to unfold and release the bound inhibitor, a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sensors (Basel)
Hauptverfasser: Yaku, Hidenobu, Murashima, Takashi, Miyoshi, Daisuke, Sugimoto, Naoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431183/
https://ncbi.nlm.nih.gov/pubmed/25905703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/s150409388
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