Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice.

Two immunotoxins were constructed by chemically coupling the monoclonal antibody C242 to Pseudomonas exotoxin A (PE) or a modified form, NlysPE40, that lacks the cell binding domain of PE. Monoclonal antibody C242 recognizes a specific sialylated carbohydrate epitope on a high molecular weight membr...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Debinski, W, Karlsson, B, Lindholm, L, Siegall, C B, Willingham, M C, FitzGerald, D, Pastan, I
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC443115/
https://ncbi.nlm.nih.gov/pubmed/1644913
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires