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Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis
BACKGROUND: EGFR is important in maintaining metabolic homeostasis in healthy cells, but in tumors it activates downstream signaling pathways, causing proliferation, angiogenesis, invasion and metastasis. Consequently, EGFR is targeted in cancers using reversible, irreversible or antibody inhibitors...
Gardado en:
| Publicado en: | BMC Cancer |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4430867/ https://ncbi.nlm.nih.gov/pubmed/25948104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1337-3 |
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