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Site-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivo
Albumin fusion/conjugation (albumination) has been an effective method to prolong in vivo half-life of therapeutic proteins. However, its broader application to proteins with complex folding pathway or multi-subunit is restricted by incorrect folding, poor expression, heterogeneity, and loss of nati...
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| Pubblicato in: | J Control Release |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4430413/ https://ncbi.nlm.nih.gov/pubmed/25862515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.04.004 |
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