LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in Parkinson's disease

Exposure to rotenone in vivo results in selective degeneration of dopaminergic neurons and development of neuropathological features of Parkinson's disease. As rotenone acts as an inhibitor of mitochondrial respiratory complex I, we employed oxidative lipidomics to assess oxidative metabolism o...

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Bibliographic Details
Published in:Free Radic Res
Main Authors: Tyurina, Yulia Y., Polimova, Anastasia M., Maciel, Elisabete, Tyurin, Vladimir A., Kapralova, Valentina I., Winnica, Daniel E., Vikulina, Anna S., Domingues, Rosario M., McCoy, Jennifer, Sanders, Laurie H., Bayır, Hülya, Greenamyre, J. Timothy, Kagan, Valerian E.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430340/
https://ncbi.nlm.nih.gov/pubmed/25740198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2015.1005085
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