LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in Parkinson's disease

Exposure to rotenone in vivo results in selective degeneration of dopaminergic neurons and development of neuropathological features of Parkinson's disease. As rotenone acts as an inhibitor of mitochondrial respiratory complex I, we employed oxidative lipidomics to assess oxidative metabolism o...

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Bibliografske podrobnosti
izdano v:Free Radic Res
Main Authors: Tyurina, Yulia Y., Polimova, Anastasia M., Maciel, Elisabete, Tyurin, Vladimir A., Kapralova, Valentina I., Winnica, Daniel E., Vikulina, Anna S., Domingues, Rosario M., McCoy, Jennifer, Sanders, Laurie H., Bayır, Hülya, Greenamyre, J. Timothy, Kagan, Valerian E.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430340/
https://ncbi.nlm.nih.gov/pubmed/25740198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2015.1005085
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