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Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia
The initiation and maintenance of a malignant phenotype requires complex and synergistic interactions of multiple oncogenic signals. The Hedgehog (HH)/GLI pathway has been implicated in a variety of cancer entities and targeted pathway inhibition is of therapeutic relevance. Signal cross-talk with o...
Gespeichert in:
| Veröffentlicht in: | Oncogene |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4430320/ https://ncbi.nlm.nih.gov/pubmed/25639866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.450 |
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