Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding tra...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Choudhry, H, Albukhari, A, Morotti, M, Haider, S, Moralli, D, Smythies, J, Schödel, J, Green, C M, Camps, C, Buffa, F, Ratcliffe, P, Ragoussis, J, Harris, A L, Mole, D R
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430310/
https://ncbi.nlm.nih.gov/pubmed/25417700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.378
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