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Hepatic Insulin Signaling is Dispensable for Suppression of Glucose Output by Insulin in Vivo
Insulin signaling and nutrient levels coordinate the metabolic response to feeding in the liver. Insulin signals in hepatocytes to activate Akt, which inhibits Foxo1 suppressing hepatic glucose production (HGP) and allowing the transition to the postprandial state. Here we provide genetic evidence t...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429930/ https://ncbi.nlm.nih.gov/pubmed/25963408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8078 |
| Oznake: |
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